Journal: Journal of Nanobiotechnology
Article Title: Epithelial cells derived exosomal miR-203a-3p facilitates stromal inflammation of type IIIA chronic prostatitis/chronic pelvic pain syndrome by targeting DUSP5 and increasing MCP-1 generation
doi: 10.1186/s12951-024-02513-5
Figure Lengend Snippet: A scheme visually represents how exosomal miR-203a-3p, originating from inflammatory prostate epithelial cells, activates the ERK1/2-MCP-1 signaling pathways. This activation occurs by decreasing the expression of DUSP5, which further promotes inflammation in stromal cell
Article Snippet: The human prostate epithelial cell line (PEC: RWPE-1 cell) and human prostate stromal cell line (PSC: WPMY-1 cell) were purchased from the American Type Culture Collection (ATCC, USA) and tested for no mycoplasma contamination.
Techniques: Protein-Protein interactions, Activation Assay, Expressing